Book chapter
Metabolic Production of H2O2 in Carcinogenesis and Cancer Treatment
Redox-Active Therapeutics, pp.103-124
Oxidative Stress in Applied Basic Research and Clinical Practice, Springer International Publishing
10/14/2016
DOI: 10.1007/978-3-319-30705-3_6
Abstract
The metabolic production of O2•− and H2O2 in the presence of redox active metal ions is known to contribute to several steps involved with initiation, promotion, and progression of carcinogenesis that can induce genomic instability, promotion of the transformed phenotype, and rapid cancer cell growth as well as progression to an aggressively malignant phenotype. However, when the metabolic production of H2O2 can be further increased selectively in cancer vs. normal cells using pharmacological approaches, H2O2 can enhance tumoricidal responses to traditional cancer therapies by selectively increasing metabolic oxidative stress. In this way, the metabolic production of H2O2 can be considered as a double-edged sword that can exert both detrimental and beneficial effects in cancer biology and therapy. This chapter discusses critical mechanistic details surrounding the pleiotropic effects of H2O2-induced metabolic oxidative stress in cancer biology and therapy that could be used to develop novel biochemical rationales for controlling cancer in humans.
Details
- Title: Subtitle
- Metabolic Production of H2O2 in Carcinogenesis and Cancer Treatment
- Creators
- Bryan G. Allen - University of Iowa Hospitals and ClinicsDouglas R. Spitz - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Redox-Active Therapeutics, pp.103-124
- Series
- Oxidative Stress in Applied Basic Research and Clinical Practice
- DOI
- 10.1007/978-3-319-30705-3_6
- eISSN
- 2197-7232
- ISSN
- 2197-7224
- Publisher
- Springer International Publishing; Cham
- Language
- English
- Date published
- 10/14/2016
- Academic Unit
- Pathology; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984314163902771
Metrics
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