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MicroRNAs and Regulatory Pathways in Tumorigenesis
Book chapter

MicroRNAs and Regulatory Pathways in Tumorigenesis

Jun Wei, Yong Li, Xiaoming Liu and William C Cho
MicroRNAs: Key Regulators of Oncogenesis, pp.209-231
Springer International Publishing
01/30/2014
DOI: 10.1007/978-3-319-03725-7_9

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Abstract

The signaling pathways have been demonstrated to invariably alter in controlling cell growth and differentiation in cancers. The understanding of complex signalings in tumorigenesis has led to the development of tumor-specific, molecularly targeted agents against a wide variety of human cancers. Recently, numerous microRNAs (miRNAs) has been identified as having an oncogenic or tumor suppressor property, shown to be involved in cell proliferation, differentiation, apoptosis, and radio- or chemo-sensitivity in cancers. Importantly, a growing body of studies has demonstrated that some of the miRNAs function as important modulators in cellular pathways and they appear to play pivotal roles in tumorigenesis, as well as the radio-resistance and/or chemo-resistance to cancer therapy regimens, suggesting miRNAs may be potential novel anticancer targets for cancers. However, the mechanisms that miRNAs target these pathways remains fragmentary, it is therefore critical to understand the underlying mechanisms and to identify targets for therapeutic intervention. This chapter aims to discuss the current understanding of mechanisms that miRNAs integrate the activity of regulatory pathways in tumorigenesis, mainly focuses on the miRNAs those target several well-defined signaling pathways with potential targets for developing anticancer agents, including the Wnt/ß-catenin, mTOR/Akt/PI3K, EGFR, VEGF and KRAS pathways.
 Cancer target Wnt signaling MicroRNA VEGF mTOR pathway KRAS EGFR

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