Book chapter
Mitochondrial Ca2+ Transport in the Control of Neuronal Functions
The Functions, Disease‐Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria, pp.101-129
John Wiley & Sons, Inc
10/27/2015
DOI: 10.1002/9781119017127.ch4
Abstract
The fact that mitochondrial Ca
2+
signaling is key to controlling neuronal life and death makes the components of mitochondrial Ca
2+
transport attractive candidates for therapeutic targeting in the treatment of neurodegenerative and psychiatric disorders. This chapter reviews recent advancements in the molecular biology of mitochondrial Ca
2+
signaling in neurons and discusses how Ca
2+
transport into and out of neuronal mitochondria contributes to the control of neuron excitability, synaptic transmission, and gene expression. In neurons at rest, total Ca
2+
concentration in the matrix ([Ca]
mt
) is low, usually <100 nM. During electrical or synaptic stimulation, [Ca]
mt
can increase to millimolar levels within seconds. Since, our knowledge of the expression and function of the MCU and MICU isoforms within various organ systems is limited, the chapter focuses on the data available for the nervous system.
Details
- Title: Subtitle
- Mitochondrial Ca2+ Transport in the Control of Neuronal Functions
- Creators
- Yuriy M Usachev - Department of Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa
- Contributors
- Valentin K Gribkoff (Editor) - Department of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USAElizabeth A Jonas (Editor) - Department of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USAJ. Marie Hardwick (Editor) - Department of Molecular Microbiology and Immunology, and Dept. of Neurology, Johns Hopkins University Bloomberg Schools of Public Health and Medicine, Baltimore, Maryland, USA
- Resource Type
- Book chapter
- Publication Details
- The Functions, Disease‐Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria, pp.101-129
- DOI
- 10.1002/9781119017127.ch4
- Publisher
- John Wiley & Sons, Inc; Hoboken, NJ
- Number of pages
- 28
- Language
- English
- Date published
- 10/27/2015
- Academic Unit
- Iowa Neuroscience Institute; Anesthesia; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology
- Record Identifier
- 9984070106502771
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