Book chapter
Modeling The Dynamics of Second Messenger Pathways
Neuroscience Databases, pp.63-79
Springer US
2002
DOI: 10.1007/978-1-4615-1079-6_5
Abstract
Understanding the effect of neuromodulators requires modeling the dynamics of second messenger pathways and their effects on channel properties. Chemesis is software for modeling enzyme reactions, stoichiometric reactions, diffusion, and ligand gating of channels and is used in conjunction with GENESIS, the software program for neuronal modeling. This chapter explains the differential equations and corresponding Chemesis objects that implement these reactions. Glutamate stimulated IP3 production and calcium waves are examples of the second messenger pathways that can be implemented in Chemesis.
Details
- Title: Subtitle
- Modeling The Dynamics of Second Messenger Pathways
- Creators
- Kim. T. Blackwell - George Mason UniversityJeanette Hellgren Kotaleski - KTH Royal Institute of Technology
- Resource Type
- Book chapter
- Publication Details
- Neuroscience Databases, pp.63-79
- DOI
- 10.1007/978-1-4615-1079-6_5
- Publisher
- Springer US; Boston, MA
- Language
- English
- Date published
- 2002
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984573818502771
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