Book chapter
Molecular Pathology of Inflammatory Bowel Disease-Associated Neoplasia
Molecular Pathology of Neoplastic Gastrointestinal Diseases, pp.173-178
Molecular Pathology Library, Springer US
12/11/2012
DOI: 10.1007/978-1-4614-6015-2_10
Abstract
Patients with inflammatory bowel diseases (ulcerative colitis and Crohn’s disease) have a greater risk of developing colorectal cancer (CRC) as compared to patients without colitis, requiring increased surveillance colonoscopy. Chronic colitis may progress to dysplasia and in turn dysplastic lesions carry a high risk of progression to adenocarcinoma.
Although many molecular players are common with sporadic colorectal carcinogenesis, since IBD-associated dysplasia and cancers are initiated in a specific inflammatory milieu, these lesions are significantly different at the molecular level. This chapter will review the most recent advances in molecular alterations observed in IBD-associated neoplastic lesions. Importantly, in view of these differences, approaches used for early detection and specific targeted therapies may differ between IBD-associated and sporadic forms of CRC and pre-cancer lesions.
Details
- Title: Subtitle
- Molecular Pathology of Inflammatory Bowel Disease-Associated Neoplasia
- Creators
- Takeshi Uehara - Shinshu UniversityDeqin Ma - University of Iowa Hospitals and ClinicsAntonia R Sepulveda - Columbia University
- Resource Type
- Book chapter
- Publication Details
- Molecular Pathology of Neoplastic Gastrointestinal Diseases, pp.173-178
- Publisher
- Springer US; Boston, MA
- Series
- Molecular Pathology Library
- DOI
- 10.1007/978-1-4614-6015-2_10
- eISSN
- 1935-9888
- ISSN
- 1935-987X
- Language
- English
- Date published
- 12/11/2012
- Academic Unit
- Pathology
- Record Identifier
- 9984201248802771
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