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Nanoscale Optical Sensors Based on Surface Plasmon Resonance
Book chapter

Nanoscale Optical Sensors Based on Surface Plasmon Resonance

Amanda J Haes, Douglas A Stuart and Richard P Van Duyne
Nanotechnology in Biology and Medicine, pp.337-370
CRC Press, 2nd Edition
2018
DOI: 10.4324/9781315374581-16

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Abstract

The development of nanodevices, including nanosensors that are highly sensitive and selective (give low false positives, low false negatives) have the potential to provide a major improvement over current technologies for disease understanding, treatment, and monitoring. Nanoscale sensors consume less sample volume than conventional instruments because their inherently small size scale in comparison to standard macroscale devices permits straightforward integration with microfluidic devices. Additionally, nanoscale systems often exhibit behavior that is markedly different from their macroscale counterparts, thereby providing alternative pathways for obtaining new information. The development of nanodevices, including nanosensors that are highly sensitive and selective have the potential to provide a major improvement over current technology for disease understanding, treatment, and monitoring. The measurement and detection of molecules and their interactions is the foundation of analytical chemistry as applied to biomedical and environmental sciences. Traditionally, advances in instrumentation and the development of novel detection modalities have resulted in the ability to monitor target species and processes previously inaccessible, generating advances in all realms of science. Currently, the most widely used optical biosensor is the surface plasmon resonance (SPR) sensor. This sensor detects changes in the refractive index induced by molecules near the surface of noble metal thin films. The biology community would like to reduce the amount of biological sample needed for an assay without amplification. A field of particular interest is the study of the interaction between antigens and antibodies.
 Single Nanoparticle Nanoparticle Arrays SPR Spectroscopy SERS Measurement Nanoparticle Aspect Ratio DDA Method Van Duyne Scattering Spectrum LSPR Biosensor Wavelength Shift SERS Detection Mica Substrate LSPR Sensing LSPR Spectrum Refractive Index Sensitivity SERS Spectrum LSPR Ag Nanoparticles Nanosphere Mask LSPR Shift Δλ Max SPR Imaging Max Shift Refractive Index SPR Sensor

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