Book chapter
Native Human and Bioprosthetic Heart Valve Dynamics
Image-Based Computational Modeling of the Human Circulatory and Pulmonary Systems, pp.403-435
Springer US
11/03/2010
DOI: 10.1007/978-1-4419-7350-4_11
Abstract
Native human heart valves undergo complex deformation during a cardiac cycle and the tissue leaflets are subjected to regions of stress concentrations particularly during the opening and closing phases. Diseases of the heart valves include stenosis and valvular incompetence and the valves in the left heart (aortic and mitral valves) subjected to higher pressure loads are more prone to these diseases. A correlation has been established between regions of high stress concentration on the leaflets and regions of calcification and tissue failure. Computational simulations play a significant role in the determination of stress distribution on the leaflets during a cardiac cycle. In this chapter, the development of state-of-the-art structural analysis of the biological leaflet valves as well as fluid–structure interaction algorithms for the analysis of biological tissue valve dynamics are described. The potential application of the computational analyses on improving the design of biological heart valve prostheses is discussed. The need for further advancements in multiscale simulation for increasing our understanding of the effect of mechanical stresses on the leaflet microstructure is also pointed out.
Details
- Title: Subtitle
- Native Human and Bioprosthetic Heart Valve Dynamics
- Creators
- Hyunggun Kim - University of Iowa, Roy J. Carver Department of Biomedical EngineeringJia Lu - University of Iowa, Mechanical EngineeringK.B Chandran - University of Iowa, Roy J. Carver Department of Biomedical Engineering
- Resource Type
- Book chapter
- Publication Details
- Image-Based Computational Modeling of the Human Circulatory and Pulmonary Systems, pp.403-435
- DOI
- 10.1007/978-1-4419-7350-4_11
- Publisher
- Springer US; Boston, MA
- Language
- English
- Date published
- 11/03/2010
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Mechanical Engineering
- Record Identifier
- 9984196625102771
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