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Neurobiology of Transverse Myelitis and Infectious Myelopathies
Book chapter

Neurobiology of Transverse Myelitis and Infectious Myelopathies

Ivana Vodopivec and Tracey A Cho
Neurobiology of Disease
Oxford University Press
08/01/2016
DOI: 10.1093/med/9780199937837.003.0153

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Abstract

Infectious agents cause spinal cord pathology by three different mechanisms: direct invasion/infection of neural tissues (i.e., infective myelitis), secondary inflammation and tissue bystander damage with or without autoimmune pathogenesis (parainfectious myelitis), or involvement of extraaxial structures (including the piaarachnoid, the dura, the epidural space, or the adjacent spinal bones or intervertebral discs), resulting in compressive or ischemic myelopathy. This chapter describes the pathogenesis and treatment of these disorders.

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