Book chapter
Neuroimaging and Neurobiology of Schizophrenia
Contemporary Neuropsychiatry, pp.265-271
Springer Japan
2001
DOI: 10.1007/978-4-431-67897-7_42
Abstract
Identifying the neural substrates of the symptoms of schizophrenia has been substantially facilitated through the use of in vivo neuroimaging techniques. Magnetic resonance (MR) and positron emission tomography (PET) studies have permitted us to identify distributed nodes on neural networks that implicate an abnormality in neural circuitry in schizophrenia. Evidence is converging to suggest that this neural circuitry may consist of distributed cortical regions that may be functionally abnormal in a task-specific way, with more consistent and persistent abnormalities in the thalamus and cerebellum. We have proposed that abnormalities in this circuit lead to a “cognitive dysmetria;” or poor coordination of mental activity, that arises from a dysfunctional cortical-cerebellar-thalamic-cortical-circuit (CCTCC) and is expressed symptomatically in the diverse clinical presentation of schizophrenia.
Details
- Title: Subtitle
- Neuroimaging and Neurobiology of Schizophrenia
- Creators
- Nancy C Andreasen
- Resource Type
- Book chapter
- Publication Details
- Contemporary Neuropsychiatry, pp.265-271
- DOI
- 10.1007/978-4-431-67897-7_42
- Publisher
- Springer Japan; Tokyo
- Language
- English
- Date published
- 2001
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984068338802771
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