Neurotropic Coronavirus Infections

Stanley Perlman; D. Lori Wheeler

doi:10.1007/978-3-319-33133-1_5

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Neurotropic Coronavirus Infections

Stanley Perlman and D. Lori Wheeler

Neurotropic Viral Infections, pp.115-148

Springer International Publishing

09/09/2016

DOI: 10.1007/978-3-319-33133-1_5

PMCID: PMC7153443

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Abstract

Neurotropic strains of the mouse hepatitis virus (MHV) cause a range of diseases in infected mice ranging from mild encephalitis with clearance of the virus followed by demyelination to rapidly fatal encephalitis. This chapter discusses the structure, life cycle, transmission, and pathology of neurotropic coronaviruses, as well as the immune response to coronavirus infection. Mice infected with neurotropic strains of MHV have provided useful systems in which to study processes of virus- and immune-mediated demyelination and virus clearance and/or persistence in the CNS, and the mechanisms of virus evasion of the immune system.

Encephalitis

SARS

MHV

Coronavirus

Demyelination

MERS

Details

Title: Subtitle: Neurotropic Coronavirus Infections
Creators: Stanley Perlman
D. Lori Wheeler
Resource Type: Book chapter
Publication Details: Neurotropic Viral Infections, pp.115-148
DOI: 10.1007/978-3-319-33133-1_5
PMCID: PMC7153443
Publisher: Springer International Publishing; Cham
Language: English
Date published: 09/09/2016
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9984070262902771

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