Book chapter
Overview of Varicella-Zoster Virus Glycoproteins gC, gH and gL
Varicella-zoster Virus, pp.113-128
Current Topics in Microbiology and Immunology, 342, Springer Berlin Heidelberg
02/26/2010
DOI: 10.1007/82_2009_4
PMID: 20186613
Abstract
The VZV genome is smaller than the HSV genome and only encodes nine glycoproteins. This chapter provides an overview of three VZV glycoproteins: gH (ORF37), gL (ORF60), and gC (ORF14). All three glycoproteins are highly conserved among the alpha herpesviruses. However, VZV gC exhibits unexpected differences from its HSV counterpart gC. In particular, both VZV gC transcription and protein expression are markedly delayed in cultured cells. These delays occur regardless of the virus strain or the cell type, and may account in part for the aberrant assembly of VZV particles. In contrast to VZV gC, the general properties of gH and gL more closely resemble their HSV homologs. VZV gL behaves as a chaperone protein to facilitate the maturation of the gH protein. The mature gH protein in turn is a potent fusogen. Its fusogenic activity can be abrogated when infected cultures are treated with monoclonal anti-gH antibodies.
Details
- Title: Subtitle
- Overview of Varicella-Zoster Virus Glycoproteins gC, gH and gL
- Creators
- Charles Grose - Department of Pediatrics/2501 JCP, University of Iowa Hospital, Iowa City, USAJohn E Carpenter - Department of Pediatrics/2501 JCP, University of Iowa Hospital, Iowa City, USAWallen Jackson - Department of Pediatrics/2501 JCP, University of Iowa Hospital, Iowa City, USAKaren M Duus - Center for Immunology, Albany Medical College, Albany, USA
- Resource Type
- Book chapter
- Publication Details
- Varicella-zoster Virus, pp.113-128
- Publisher
- Springer Berlin Heidelberg; Berlin, Heidelberg
- Series
- Current Topics in Microbiology and Immunology; 342
- DOI
- 10.1007/82_2009_4
- PMID
- 20186613
- ISSN
- 0070-217X
- Language
- English
- Date published
- 02/26/2010
- Academic Unit
- Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093227302771
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