Book chapter
Oxidative Conditioning and Treatment for Osteoarthritis
Studies on Arthritis and Joint Disorders, pp.311-332
Oxidative Stress in Applied Basic Research and Clinical Practice, Springer New York
12/24/2012
DOI: 10.1007/978-1-4614-6166-1_17
Abstract
Oxidative stress is associated with aging and is also implicated as a contributing factor in osteoarthritis, a degenerative joint disease resulting mainly due to progressive degradation of the articular cartilage. Avascular and aneural in nature, articular cartilage is a unique tissue thriving in a mechanically active environment that requires physical stimuli to maintain tissue health. Cartilage adaptation is achieved by modulating matrix synthesis and other protective biological features in an effort to tolerate increased mechanical demands. One potential mechano-transductive pathway that regulates functional adaptation is believed to be driven by oxidative stress, but the exact mechanisms of this phenomenon are not clear. As an important rate-limiting factor for cartilage metabolism, sublethal levels of oxidants play a protective role against injurious mechanical loads, probably by modulating multiple biochemical pathways that increase stress tolerance thresholds of cartilage. Antioxidant status, nuclear factor (NF-κB), and hypoxia-inducible factor (HIF-1α) are potential factors that may play a role in oxidant conditioning and cartilage adaptation.
Details
- Title: Subtitle
- Oxidative Conditioning and Treatment for Osteoarthritis
- Creators
- Prem S. Ramakrishnan - University of IowaMarc J. Brouillette - University of IowaJames A. Martin - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Studies on Arthritis and Joint Disorders, pp.311-332
- Series
- Oxidative Stress in Applied Basic Research and Clinical Practice
- DOI
- 10.1007/978-1-4614-6166-1_17
- Publisher
- Springer New York; New York, NY
- Language
- English
- Date published
- 12/24/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Orthopedics and Rehabilitation
- Record Identifier
- 9984303976402771
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