Book chapter
Oxidative Stress and Diabetes-Induced Vascular Dysfunction: Role in Diabetic Neuropathy
Studies in Diabetes, pp.1-12
Oxidative Stress in Applied Basic Research and Clinical Practice, Springer New York
01/24/2014
DOI: 10.1007/978-1-4899-8035-9_1
Abstract
This review will focus on the impact of hyperglycemia-induced oxidative stress in the development of diabetes-induced vascular and neural dysfunction. Oxidative stress occurs when the balance between the production of oxidation products and the ability of antioxidant mechanisms to neutralize these products is tilted in the favor of the former. The production of reactive oxygen species has been shown to be increased in patients with diabetes. The possible sources for the overproduction of reactive oxygen species are widespread and include enzymatic pathways, autoxidation of glucose, and the mitochondria. Increase in oxidative stress has clearly been shown to contribute to the pathology of vascular disease not only in diabetes but also in hypertension, stroke, and ischemia. Since the etiology of diabetic neuropathy is considered to have a large vascular component, prevention of oxidative stress in diabetes is considered by many investigators to be a primary defense against the development of diabetic vascular disease. Moreover, increased oxidative stress has been promoted as a unifying hypothesis for diabetic complications.
Details
- Title: Subtitle
- Oxidative Stress and Diabetes-Induced Vascular Dysfunction: Role in Diabetic Neuropathy
- Creators
- Mark A. Yorek - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Studies in Diabetes, pp.1-12
- Publisher
- Springer New York; New York, NY
- Series
- Oxidative Stress in Applied Basic Research and Clinical Practice
- DOI
- 10.1007/978-1-4899-8035-9_1
- eISSN
- 2197-7232
- ISSN
- 2197-7224
- Language
- English
- Date published
- 01/24/2014
- Academic Unit
- Endocrinology and Metabolism; Internal Medicine; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984363453002771
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