Book chapter
PKA Anchoring and Synaptic Tagging and Capture
Synaptic Tagging and Capture, pp.61-78
Springer New York
09/24/2014
DOI: 10.1007/978-1-4939-1761-7_5
Abstract
Synaptic tagging and capture (STC) hypothesis has been receiving increasing attention because it reflects heterosynaptic association of information processing during memory formation in the brain. Indeed, electrophysiological and behavioral studies suggest that STC is a better cellular model for memory formation than the conventional homosynaptic experiment. In STC, a short-lasting potentiation in one pathway becomes persistent when it is paired with a long-lasting potentiation in the other independent pathway. It has been proposed that the setting of synapse-specific tag and capture of non-synapse-specific diffusible gene products by the tag determines the fate of each pathway. However, the mechanism of STC is still elusive and three major questions should be answered: (1) What is the tag and how does it modulate synapse-specific plasticity? (2) How does the tag capture gene products? (3) What are the gene products and how are they produced? Although several molecules and processes have been suggested to answer to these questions, they only provide partial explanations about the phenomenon. Here, this article will discuss how PKA modulates synapse-specific neuronal processing by coordinating signaling molecules and processes through PKA anchoring proteins, and how anchored PKA is involved in the generation and capture of plasticity-related gene products. Having PKA as a key molecule, the goal of this article is to provide a unified model of STC that addresses the key questions.
Details
- Title: Subtitle
- PKA Anchoring and Synaptic Tagging and Capture
- Creators
- Alan Jung Park - Department of Biology, University of Pennsylvania, Philadelphia, USATed Abel - Department of Biology, University of Pennsylvania, Philadelphia, USA
- Resource Type
- Book chapter
- Publication Details
- Synaptic Tagging and Capture, pp.61-78
- DOI
- 10.1007/978-1-4939-1761-7_5
- Publisher
- Springer New York; New York, NY
- Language
- English
- Date published
- 09/24/2014
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984070244702771
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