Book chapter
Pediatric Patients with Bone Malignancy: Therapeutic Options
Pediatric Cancer, Volume 4, pp.311-320
Pediatric Cancer, Springer Netherlands
04/23/2013
DOI: 10.1007/978-94-007-6591-7_31
Abstract
Primary bone malignancy, namely osteosarcoma and Ewing sarcoma, is predominantly encountered in the pediatric population. After histological confirmation of diagnosis done through a carefully performed biopsy these malignant tumors are generally treated with neoadjuvant chemotherapy and wide surgical resection, followed by adjuvant chemotherapy. Reconstructive options after resection depend on tumor size and location as well as patient age and goals. Limb ablation, either by amputation or rotationplasty, is commonly a less appealing option although the literature supports excellent long-term outcomes and durability. As a result of improved neoadjuvant regimens limb sparing surgery has become the mainstay of surgical treatment for the vast majority of bone tumors. Limb sparing options primarily include allograft reconstruction, allograft prosthetic composite reconstruction, and megaprosthesis reconstruction with or without expansion capabilities. Each of these options has features that make them attractive as well as potential complications. The choice of reconstruction should be made after in-depth discussion of the benefits, alternatives and potential complications on a patient by patient basis.
Details
- Title: Subtitle
- Pediatric Patients with Bone Malignancy: Therapeutic Options
- Creators
- Lukas M. Nystrom - Loyola University ChicagoJose A. Morcuende - University of Iowa Hospitals and Clinics
- Resource Type
- Book chapter
- Publication Details
- Pediatric Cancer, Volume 4, pp.311-320
- Publisher
- Springer Netherlands; Dordrecht
- Series
- Pediatric Cancer
- DOI
- 10.1007/978-94-007-6591-7_31
- eISSN
- 2211-8004
- ISSN
- 2211-7997
- Language
- English
- Date published
- 04/23/2013
- Academic Unit
- Stead Family Department of Pediatrics; Orthopedics and Rehabilitation
- Record Identifier
- 9984305877602771
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