Peptide Amidation

M.J Niciu; R.E Mains; B.A Eipper

doi:10.1016/B978-0-12-378630-2.00019-0

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Book chapter

Peptide Amidation

M.J Niciu, R.E Mains and B.A Eipper

Encyclopedia of Biological Chemistry, pp.396-399

Elsevier Inc, Second Edition

2013

DOI: 10.1016/B978-0-12-378630-2.00019-0

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Abstract

The PAM gene encodes a copper-dependent monooxygenase and a zinc-dependent lyase that act sequentially to produce amidated, bioactive peptides from their inactive glycine-extended precursors. This type 1 membrane protein functions in secretory granules and is recycled following exocytosis. PAM is essential for life and mice heterozygous for PAM show multiple behavioral deficits.

Molecular oxygen

Secretory granule

PHM

Ascorbate

PAL

Copper

Monooxygenase

PAM

Zinc

Details

Title: Subtitle: Peptide Amidation
Creators: M.J Niciu
R.E Mains
B.A Eipper
Resource Type: Book chapter
Publication Details: Encyclopedia of Biological Chemistry, pp.396-399
Edition: Second Edition
DOI: 10.1016/B978-0-12-378630-2.00019-0
Publisher: Elsevier Inc
Language: English
Date published: 2013
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984070836602771

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