Book chapter
Peroxisome Proliferator Activated Receptor-γ (PPARγ): Roles in Chronic Inflammation and Intestinal Oncogenic Transformation
From Inflammation To Cancer, pp.277-296
WORLD SCIENTIFIC
10/2012
DOI: 10.1142/9789814343602_0013
Abstract
PPARγ is a nuclear receptor transcription factor involved in both carcinogenesis and inflammation. It displays a high expression in adipose tissue controlling adipogenesis and fat metabolism but is also expressed in equivalent levels in colorectal tissue where it plays a role in metabolism but also in signal transduction, proliferation and motility. PPARγ roles in inflammatory bowel disease and in colorectal cancer have been studied and some of their aspects have been elucidated. An inflammation- suppressing effect of PPARγ seems to emerge in most experimental models. Additionally, PPARγ has anti-tumor effects in most models of inflammation-induced but also sporadic carcinogenesis. The current knowledge on PPARγ in these processes and perspectives on therapeutic opportunities will be the subject of this paper.
Details
- Title: Subtitle
- Peroxisome Proliferator Activated Receptor-γ (PPARγ): Roles in Chronic Inflammation and Intestinal Oncogenic Transformation
- Creators
- Ioannis A. Voutsadakis - University Hospital of Larissa
- Contributors
- Chi Hin Cho (Editor) - Chinese University of Hong KongJun Yu (Editor) - Chinese University of Hong Kong
- Resource Type
- Book chapter
- Publication Details
- From Inflammation To Cancer, pp.277-296
- DOI
- 10.1142/9789814343602_0013
- Publisher
- WORLD SCIENTIFIC
- Number of pages
- 20
- Language
- English
- Date published
- 10/2012
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984806608102771
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