Book chapter
Physiological Functions and Pathological Significance of NADPH Oxidase 3
NADPH Oxidases Revisited: From Function to Structure, pp.165-177
Springer International Publishing
01/01/2023
DOI: 10.1007/978-3-031-23752-2_11
Abstract
NADPH oxidase 3 (NOX3) is the catalytic subunit of a superoxide-producing enzyme complex in the inner ear. Other subunits of this complex include p22phox and NOX organizer 1 (NOXO1). Both of these accessory proteins are essential for the enzymatic activity of NOX3, with p22phox stabilizing, and NOXO1 activating it. In mice, deleterious mutations in the genes that encode any of these subunits cause a balance defect and a complete lack of calcium carbonate crystals (otoconia) in the gravity-sensing organs (utricle and saccule) of the inner ear. Consistent with a role in the genesis of otoconia, the NOX3-containing enzyme complex is expressed adjacent to the utricle and saccule, in the endolymphatic sac and duct. NOX3 and p22phox are also expressed in the cochlea, and NOX3 is likely enzymatically active and pathogenic at this location because inactivating mutations protect mice from distinct types of acquired hearing loss. Thus, NOX3 plays both developmental and pathological roles in the inner ear. Finally, a few studies have linked NOX3 to physiological and pathological processes outside the inner ear. In this chapter we summarize key discoveries related to the expression pattern, interacting partners, physiological functions, and pathological effects of NOX3.
Details
- Title: Subtitle
- Physiological Functions and Pathological Significance of NADPH Oxidase 3
- Creators
- Yoko NakanoBotond Bánfi
- Resource Type
- Book chapter
- Publication Details
- NADPH Oxidases Revisited: From Function to Structure, pp.165-177
- Publisher
- Springer International Publishing
- DOI
- 10.1007/978-3-031-23752-2_11
- Language
- English
- Date published
- 01/01/2023
- Academic Unit
- Internal Medicine; Anatomy and Cell Biology; Otolaryngology
- Record Identifier
- 9984442226602771
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