Book chapter
Post-translational modifications of lysine in DNA-damage repair
Essays in biochemistry, pp.93-111
Essays in Biochemistry, Portland Press Ltd
01/01/2012
DOI: 10.1042/BSE0520093
PMID: 22708566
Abstract
DNA damage in cells is often the result of constant genotoxic insult. Nevertheless, efficient DNA repair pathways are able to maintain genomic integrity. Over the past decade it has been revealed that it is not only kinase signalling pathways which play a central role in this process, but also the different post-translational modifications at lysine residues of histone (chromatin) and non-histone proteins. These lysine modifications include acetylation, methylation, ubiquitination and SUMOylation. Genomic instability is often the major cause of different diseases, especially cancer, where lysine modifications are altered and thereby have an impact on the various DNA repair mechanisms. This chapter will discuss the recent advances in our understanding of the role of different lysine modifications in DNA repair and its physiological consequences.
Details
- Title: Subtitle
- Post-translational modifications of lysine in DNA-damage repair
- Creators
- Snehajyoti Chatterjee - Jawaharlal Nehru Centre for Advanced Scientific ResearchParijat Senapati - Jawaharlal Nehru Centre for Advanced Scientific ResearchTapas K. Kundu - Jawaharlal Nehru Centre for Advanced Scientific Research
- Contributors
- Iain Scott (Editor)
- Resource Type
- Book chapter
- Publication Details
- Essays in biochemistry, pp.93-111
- Series
- Essays in Biochemistry
- DOI
- 10.1042/BSE0520093
- PMID
- 22708566
- NLM abbreviation
- Essays Biochem
- eISSN
- 1744-1358
- ISSN
- 0071-1365
- Publisher
- Portland Press Ltd; LONDON
- Number of pages
- 19
- Language
- English
- Date published
- 01/01/2012
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984303854302771
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