Book chapter
Postoperative Radiation for Head and Neck Cancer
Essentials of Clinical Radiation Oncology
Springer Publishing Company, Second edition
2021
DOI: 10.1891/9780826169099.0017
Abstract
Surgery is the preferred initial management of resectable head and neck (H&N) cancers of oral cavity, salivary gland, nasal cavity/paranasal sinuses, thyroid, and some oropharynx and larynx cancers. Adjuvant radiation therapy (postoperative radiation therapy) is recommended for specific pathologic risk factors with concurrent chemotherapy (CHT) given for positive margins and extracapsular extension in mucosal H&N squamous cell carcinoma (HNSCC). Most common histology is squamous cell carcinoma: “keratin pearls” are seen in well-differentiated SCC, often associated with classic HNSCC related to smoking/alcohol abuse; nonkeratinizing poorly differentiated “basaloid” squamous cancer often associated with human papillomavirus-associated p16+ oropharyngeal SCC. Other histologies include mucoepidermoid carcinoma, adenoid cystic carcinoma, adenosquamous, adenocarcinoma, acinic cell, lymphoma, lymphoepithelial carcinoma, and melanoma. Aggressive radiation therapy de-escalation resulted in locoregional tumor control rates comparable to historical controls, low toxicity, and decrement in swallowing function or quality of life.
Details
- Title: Subtitle
- Postoperative Radiation for Head and Neck Cancer
- Creators
- Timothy D. SmileCarryn M. Anderson
- Resource Type
- Book chapter
- Publication Details
- Essentials of Clinical Radiation Oncology
- Edition
- Second edition
- Publisher
- Springer Publishing Company; New York
- DOI
- 10.1891/9780826169099.0017
- Language
- English
- Date published
- 2021
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984531760202771
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