Logo image
Practical Guidelines for Cerenkov Luminescence Imaging with Clinically Relevant Isotopes
Book chapter   Open access

Practical Guidelines for Cerenkov Luminescence Imaging with Clinically Relevant Isotopes

Nikunj B. Bhatt, Darpan N. Pandya, William A. Dezarn, Frank C. Marini, Dawen Zhao, William H. Gmeiner, Pierre L. Triozzi and Thaddeus J. Wadas
Methods in molecular biology (Clifton, N.J.), pp.197-208
Methods in Molecular Biology, Humana Press Inc
01/01/2018
DOI: 10.1007/978-1-4939-7860-1_15
PMCID: PMC6734187
PMID: 29858793
url
https://www.ncbi.nlm.nih.gov/pmc/articles/6734187View
Open Access

Abstract

Cerenkov luminescence imaging (CLI) is a relatively new imaging modality that utilizes conventional optical imaging instrumentation to detect Cerenkov radiation derived from standard and often clinically approved radiotracers. Its research versatility, low cost, and ease of use have increased its popularity within the molecular imaging community and at institutions that are interested in conducting radiotracer-based molecular imaging research, but that lack the necessary resources and infrastructure. Here, we provide a description of the materials and procedures necessary to conduct a Cerenkov luminescence imaging experiment using a variety of imaging instrumentation, radionuclides, and animal models.
Biochemical Research Methods Biochemistry & Molecular Biology Life Sciences & Biomedicine Radiology, Nuclear Medicine & Medical Imaging Science & Technology

Details

Metrics

Logo image