Book chapter
Psychoneuroimmunology and Cancer: Biobehavioral Influences on Tumor Progression
The Oxford Handbook of Psychoneuroimmunology
Oxford Library of Psychology, Oxford University Press
07/03/2012
DOI: 10.1093/oxfordhb/9780195394399.013.0019
Abstract
This chapter examines the role of psychosocial factors and stress-related neuroendocrine hormones in cancer progression. The neuroendocrine stress response appears to play a key role in modulating physiological pathways relevant to cancer progression. These include tumor angiogenesis, invasion, anoikis, inflammation, the cellular immune response, and various cell-signaling pathways. These stress-response pathways also potentially interact with cancer treatments. Bidirectional influences of tumor-derived cytokines and other molecules on the hypothalamic pituitary adrenal (HPA) axis and CNS processes are also discussed along with implications for disease progression and survival. These mechanisms point to emerging possibilities for psychosocial, pharmacological, and integrative medicine interventions that have the potential to alter stress-response signaling pathways in cancer.
Details
- Title: Subtitle
- Psychoneuroimmunology and Cancer: Biobehavioral Influences on Tumor Progression
- Creators
- Sally S DickersonSusan K LutgendorfMichael H AntoniAnil K SoodErin S Costanzo
- Contributors
- Suzanne C Segerstrom (Editor)
- Resource Type
- Book chapter
- Publication Details
- The Oxford Handbook of Psychoneuroimmunology
- Series
- Oxford Library of Psychology
- DOI
- 10.1093/oxfordhb/9780195394399.013.0019
- Publisher
- Oxford University Press
- Language
- English
- Date published
- 07/03/2012
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
- Record Identifier
- 9984065879802771
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