Reactive Oxygen Species in Normal and Tumor Stem Cells

Daohong Zhou; Lijian Shao; Douglas R Spitz

doi:10.1016/B978-0-12-420117-0.00001-3

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Reactive Oxygen Species in Normal and Tumor Stem Cells

Book chapter

Open access

Peer reviewed

Reactive Oxygen Species in Normal and Tumor Stem Cells

Daohong Zhou, Lijian Shao and Douglas R Spitz

Advances in Cancer Research, pp.1-67

Elsevier Science & Technology

2014

DOI: 10.1016/B978-0-12-420117-0.00001-3

PMCID: PMC4207279

PMID: 24974178

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Abstract

Reactive oxygen species (ROS) play an important role in determining the fate of normal stem cells. Low levels of ROS are required for stem cells to maintain quiescence and self-renewal. Increases in ROS production cause stem cell proliferation/differentiation, senescence, and apoptosis in a dose-dependent manner, leading to their exhaustion. Therefore, the production of ROS in stem cells is tightly regulated to ensure that they have the ability to maintain tissue homeostasis and repair damaged tissues for the life span of an organism. In this chapter, we discuss how the production of ROS in normal stem cells is regulated by various intrinsic and extrinsic factors and how the fate of these cells is altered by the dysregulation of ROS production under various pathological conditions. In addition, the implications of the aberrant production of ROS by tumor stem cells for tumor progression and treatment are also discussed.

Apoptosis

Hypoxia

Reactive oxygen species

Senescence

Ionizing radiation

Adult stem cells

Tumor stem cells

Embryonic stem cells

Differentiation

Hematopoietic stem cells

Details

Title: Subtitle: Reactive Oxygen Species in Normal and Tumor Stem Cells
Creators: Daohong Zhou - Division of Radiation Health, Department of Pharmaceutical Sciences, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Lijian Shao - Division of Radiation Health, Department of Pharmaceutical Sciences, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Douglas R Spitz - Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA
Resource Type: Book chapter
Publication Details: Advances in Cancer Research, pp.1-67
DOI: 10.1016/B978-0-12-420117-0.00001-3
PMID: 24974178
PMCID: PMC4207279
NLM abbreviation: Adv Cancer Res
eISSN: 2162-5557
ISSN: 0065-230X
Publisher: Elsevier Science & Technology
Language: English
Date published: 2014
Academic Unit: Pathology; Radiation Oncology
Record Identifier: 9984047779002771

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