Book chapter
Recurrent Disease Challenges in Pediatric Kidney Transplantation
Challenges in Pediatric Kidney Transplantation, pp.223-244
Springer International Publishing
06/27/2021
DOI: 10.1007/978-3-030-74783-1_8
Abstract
Recurrence of disease accounts for 7–8% of graft losses following pediatric kidney transplantation. Transplant planning for a child requires a thorough understanding of the underlying cause of end-stage kidney disease (ESKD), the overall risk of recurrence, and the impact of age, gender, pre- transplant course, native kidney histology, race, native kidney nephrectomy, donor source, HLA typing, and immunosuppression on disease recurrence risk. Our understanding of disease recurrence risk and treatments is limited by the lack of systematic, randomized studies, particularly in pediatric patients. This chapter reviews the nature and frequency of the primary disease, considerations for transplant planning, risk factors for recurrence, and treatment of disease recurrence in the allograft for atypical HUS, C3 glomerulopathy, IgA nephropathy, IgA vasculitis, lupus nephritis, membranous nephropathy, and primary hyperoxaluria type 1. Recurrence of focal segmental glomerulosclerosis is covered separately in another chapter.
Details
- Title: Subtitle
- Recurrent Disease Challenges in Pediatric Kidney Transplantation
- Creators
- Lyndsay A HarshmanSharon M Bartosh
- Resource Type
- Book chapter
- Publication Details
- Challenges in Pediatric Kidney Transplantation, pp.223-244
- DOI
- 10.1007/978-3-030-74783-1_8
- Publisher
- Springer International Publishing; Cham
- Language
- English
- Date published
- 06/27/2021
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984093454002771
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