Recurrent non-reciprocal translocations of chromosome 5 in primary T(12;15)-positive BALB/c plasmacytomas

A E Coleman; T Ried; S Janz

doi:10.1007/978-3-642-60162-0_22

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Recurrent non-reciprocal translocations of chromosome 5 in primary T(12;15)-positive BALB/c plasmacytomas

Book chapter

Peer reviewed

Recurrent non-reciprocal translocations of chromosome 5 in primary T(12;15)-positive BALB/c plasmacytomas

A E Coleman, T Ried and S Janz

Mechanisms of B Cell Neoplasia 1998, pp.175-181

Current topics in microbiology and immunology, 246, Springer

1999

DOI: 10.1007/978-3-642-60162-0_22

PMID: 10396054

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Abstract

The majority of inflammation-induced peritoneal BALB/c plasmacytomas (approximately 90%) harbor a balanced T(12;15) chromosomal translocation that deregulates the expression of the proto-oncogene c-myc. Recent evidence suggests that the T(12;15) is an initiating tumorigenic mutation that occurs in early plasmacytoma precursor cells. However, plasmacytomas take a long time to develop (average tumor latency approximately 220 days), which suggests that additional tumor progression events may be required to complete oncogenesis. We hypothesized that such tumor progression events may take the form of secondary chromosomal aberrations that can be detected by spectral karyotyping (SKY). We screened the entire chromosome complement of 18 primary BALB/c plasmacytomas carrying the T(12;15) and found in nine tumors (50% recurrence) secondary cytogenetic aberrations that involved bands D, E and F chromosome (Chr) 5. The Chr 5D-F rearrangements were manifested predominantly as unbalanced translocations with various partner chromosomes. This finding led us to propose the existence of an important plasmacytoma progression locus in the central region of Chr 5, which presumably becomes involved in peritoneal plasmacytoma development by promiscuous chromosomal translocations.

Karyotyping - methods

Peritoneal Neoplasms - etiology

Translocation, Genetic

Animals

Peritoneal Neoplasms - genetics

Chromosome Aberrations

Plasmacytoma - genetics

Mice

Mice, Inbred BALB C

Plasmacytoma - etiology

Details

Title: Subtitle: Recurrent non-reciprocal translocations of chromosome 5 in primary T(12;15)-positive BALB/c plasmacytomas
Creators: A E Coleman - Laboratory of Genetics, NCI, NIH, Bethesda, MD, USA
T Ried
S Janz
Resource Type: Book chapter
Publication Details: Mechanisms of B Cell Neoplasia 1998, pp.175-181
Publisher: Springer; Berlin
Series: Current topics in microbiology and immunology; 246
DOI: 10.1007/978-3-642-60162-0_22
PMID: 10396054
ISSN: 0070-217X
Language: English
Date published: 1999
Academic Unit: Pathology
Record Identifier: 9984083823202771

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