Regulation of cerebrovascular cyclooxygenase-2 by pro- and anti-inflammatory cytokines

S A Moore; E Yoder; G Rich; M Hilfers; J Albright

doi:10.1007/978-1-4615-4793-8_19

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Regulation of cerebrovascular cyclooxygenase-2 by pro- and anti-inflammatory cytokines

Book chapter

Peer reviewed

Regulation of cerebrovascular cyclooxygenase-2 by pro- and anti-inflammatory cytokines

S A Moore, E Yoder, G Rich, M Hilfers and J Albright

Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4, pp.125-129

Advances in experimental medicine and biology, 469, Springer

1999

DOI: 10.1007/978-1-4615-4793-8_19

PMID: 10667320

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Abstract

Arachidonic acid metabolism is important in regulating the cerebral circulation and its response to CNS injury (1,2), a response that often involves vascular cell proliferation, inflammatory cell infiltrates, and glial cell reactions. Induction and regulation of cyclooxygenase-2 (COX-2) may be important in these processes. Since a number of pro-and anti-inflammatory cytokines, including TGFβ1, TNFα, and IL-1β, are produced during the course of CNS reaction to injury(3,4,5), we investigated the regulation of cerebrovascular COX-2 expression by these agents. In addition to cytokine production, the release of polyunsaturated fatty acids (PUFA), particularly arachidonic acid (20:4n-6) and docosahexaenoic acid (22:6n-3), is a common early reaction to CNS injury (6,7). Therefore, the potential interactions of PUFA and proinflammatory cytokines in the regulation of COX-2 were also investigated.

Animals

Arachidonic Acid - pharmacology

Cells, Cultured

Cerebrovascular Circulation - drug effects

Cerebrovascular Circulation - physiology

Cyclooxygenase 2

Cytokines - pharmacology

Docosahexaenoic Acids - pharmacology

Endothelium, Vascular - drug effects

Endothelium, Vascular - enzymology

Enzyme Induction - drug effects

Fatty Acids, Unsaturated - pharmacology

Inflammation - prevention & control

Inflammation Mediators - pharmacology

Interleukin-1 - pharmacology

Isoenzymes - biosynthesis

Mice

Muscle, Smooth, Vascular - drug effects

Muscle, Smooth, Vascular - enzymology

Prostaglandin-Endoperoxide Synthases - biosynthesis

Tumor Necrosis Factor-alpha - pharmacology

Details

Title: Subtitle: Regulation of cerebrovascular cyclooxygenase-2 by pro- and anti-inflammatory cytokines
Creators: S A Moore - University of Iowa
E Yoder
G Rich
M Hilfers
J Albright
Resource Type: Book chapter
Publication Details: Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 4, pp.125-129
Publisher: Springer; New York, NY
Series: Advances in experimental medicine and biology; 469
DOI: 10.1007/978-1-4615-4793-8_19
PMID: 10667320
ISSN: 0065-2598
eISSN: 2214-8019
Grant note: NS-24621 / NINDS NIH HHS NS-09858 / NINDS NIH HHS
Language: English
Date published: 1999
Academic Unit: Pathology
Record Identifier: 9984201524602771

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