Book chapter
Robust Cortical Thickness Measurement with LOGISMOS-B
Medical Image Computing and Computer-Assisted Intervention – MICCAI 2014, pp.722-730
Lecture Notes in Computer Science, Springer International Publishing
2014
DOI: 10.1007/978-3-319-10404-1_90
PMID: 25333183
Abstract
Cortical thickness (CT) is an important morphometric measure that has implications for psychiatric and neurologic processes. We propose a novel approach for automatically computing CT in an accurate and robust manner using LOGISMOS-B: Layered Optimal Graph Image Segmentation of Multiple Objects and Surfaces for the Brain. LOGISMOS-B is a cortical surface segmentation method based on LOGISMOS graph segmentation and generalized gradient vector flows. We evaluate our method on two different datasets (n = 83 total). The results show that LOGISMOS-B is more accurate than the popular FreeSurfer (FS) method and provides more reliable thickness measurements across a variety of challenging images. LOGISMOS-B accurately recovers known CT patterns, both across cortical lobes and locally, such as between the banks of the central sulcus, in healthy subjects and MS patients. Manual landmarks indicate a signed surface distance of 0.081±0.447mm for WM and 0.018±0.498mm for LOGISMOS-B, compared to 0.263±0.452mm for WM and − 0.167±0.556mm for GM for FS, highlighting the surface placement accuracy of LOGISMOS-B. Finally, a regresion study shows that LOGISMOS-B provides strong correlation with age and plausible annual thinning rates across the cortex, with locally discerning thinning patterns, in agreement with the literature.
Details
- Title: Subtitle
- Robust Cortical Thickness Measurement with LOGISMOS-B
- Creators
- Ipek Oguz - University of IowaMilan Sonka - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Medical Image Computing and Computer-Assisted Intervention – MICCAI 2014, pp.722-730
- Series
- Lecture Notes in Computer Science
- DOI
- 10.1007/978-3-319-10404-1_90
- PMID
- 25333183
- eISSN
- 1611-3349
- ISSN
- 0302-9743
- Publisher
- Springer International Publishing; Cham
- Language
- English
- Date published
- 2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Psychiatry; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984186599502771
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