Book chapter
Role of Gene Transcription in Long-Term Memory Storage
Encyclopedia of Behavioral Neuroscience, Three-Volume Set, 1- 3, pp.161-179
2010
DOI: 10.1016/B978-0-08-045396-5.00030-0
Abstract
The formation of long-term memories requires the synthesis of new mRNA. Genetic approaches over the past several decades have identified signaling transduction mechanisms and transcription factors that guide this process and genes that have increased expression after learning. The expression patterns of these genes are elucidating systems- and network-level questions about learning and memory. Recent studies suggest that the epigenetic modifications that regulate transcription are critical for memory storage. Thus, genetic studies have demonstrated that memory formation requires molecular processes that regulate neuronal transcription after learning and suggest that the epigenetic modifications may store information that guides behavior.
Details
- Title: Subtitle
- Role of Gene Transcription in Long-Term Memory Storage
- Creators
- J HawkT Abel
- Resource Type
- Book chapter
- Publication Details
- Encyclopedia of Behavioral Neuroscience, Three-Volume Set, 1- 3, pp.161-179
- DOI
- 10.1016/B978-0-08-045396-5.00030-0
- Language
- English
- Date published
- 2010
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984070577202771
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