Book chapter
Role of Inducible Nitric Oxide Synthase (iNOS) in Regulation of Nitric Oxide (NO) Production and Stabilization of HIF-1α: Potential Role of Se-Methylselenocysteine (MSC), an Antioxidant Multi-targeted Small Molecule
Nitric Oxide (NO) and Cancer, pp.479-488
Cancer Drug Discovery and Development, Springer New York
04/08/2010
DOI: 10.1007/978-1-4419-1432-3_25
Abstract
The authors of chapters presented in Part VII dealt with the therapeutic application of nitric oxide (NO). The authors extensively reviewed the field demonstrating the potential therapeutic value of NO donors alone and in combination with cytotoxic therapy in the treatment of various solid tumor types. The authors indicate that while the mechanisms of activity of these agents may vary according to tumor type and treatment conditions, the fact that these agents have minimal toxicity profile and therefore potentially selective in their effects provide the scientific rationale for their continued development at the basic level and more importantly, the need to validate the clinical potential of this interesting class of relatively non-toxic agents with significant biological and therapeutic potential. This opinion is offered relevant to the data presented in Part VII and offers new and novel approaches on the potential role of Se-methylselenocysteine (MSC) on the expression levels of hypoxia-inducible factor 1α (HIF-1α) and its transcriptionally regulated genes, including vascular endothelial growth factor (VEGF), in therapy of squamous cell carcinoma of the head and neck. The use of MSC as a multi-targeted, non-toxic inhibitor of iNOS and other biomarkers such as COX-2, HIF-1α, and VEGF as therapeutic modulators of anticancer drugs against established tumors in xenografts is discussed.
Details
- Title: Subtitle
- Role of Inducible Nitric Oxide Synthase (iNOS) in Regulation of Nitric Oxide (NO) Production and Stabilization of HIF-1α: Potential Role of Se-Methylselenocysteine (MSC), an Antioxidant Multi-targeted Small Molecule
- Creators
- Sreenivasulu Chintala - Roswell Park Cancer InstituteShousong Cao - Roswell Park Cancer InstituteYoucef M. Rustum - Roswell Park Cancer Institute
- Resource Type
- Book chapter
- Publication Details
- Nitric Oxide (NO) and Cancer, pp.479-488
- Publisher
- Springer New York; New York, NY
- Series
- Cancer Drug Discovery and Development
- DOI
- 10.1007/978-1-4419-1432-3_25
- Language
- English
- Date published
- 04/08/2010
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984363186502771
Metrics
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