Book chapter
Selenoproteins in Tumorigenesis and Cancer Progression
Advances in cancer research, pp.49-83
Advances in Cancer Research, Elsevier
01/01/2017
DOI: 10.1016/bs.acr.2017.08.002
PMCID: PMC5819884
PMID: 29054422
Abstract
Selenium is a micronutrient essential to human health and has long been associated with cancer prevention. Functionally, these effects are thought to be mediated by a class of selenium-containing proteins known as selenoproteins. Indeed, many selenoproteins have antioxidant activity which can attenuate cancer development by minimizing oxidative insult and resultant DNA damage. However, oxidative stress is increasingly being recognized for its "double-edged sword"effect in tumorigenesis, whereby it can mediate both negative and positive effects on tumor growth depending on the cellular context. In addition to their roles in redox homeostasis, recent work has also implicated selenoproteins in key oncogenic and tumor-suppressive pathways. Together, these data suggest that the overall contribution of selenoproteins to tumorigenesis is complicated and may be affected by a variety of factors. In this review, we discuss what is currently known about selenoproteins in tumorigenesis with a focus on their contextual roles in cancer development, growth, and progression.
Details
- Title: Subtitle
- Selenoproteins in Tumorigenesis and Cancer Progression
- Creators
- Sarah P. Short - Vanderbilt University Medical CenterChristopher S. Williams - Vanderbilt University Medical Center
- Contributors
- K D Tew (Editor)F Galli (Editor)
- Resource Type
- Book chapter
- Publication Details
- Advances in cancer research, pp.49-83
- Series
- Advances in Cancer Research
- DOI
- 10.1016/bs.acr.2017.08.002
- PMID
- 29054422
- PMCID
- PMC5819884
- NLM abbreviation
- Adv Cancer Res
- eISSN
- 2162-5557
- ISSN
- 0065-230X
- Publisher
- Elsevier; SAN DIEGO
- Number of pages
- 35
- Grant note
- K08 DK080221; R01 DK099204; F32 DK108492 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) 1I01BX001426-01A1 / VA; US Department of Veterans Affairs I01 BX001426 / BLRD VA I01BX001426 / Veterans Affairs; US Department of Veterans Affairs F32DK108492 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 01/01/2017
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984420943002771
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