Book chapter
Serotonin neurons and central respiratory chemoreception: where are we now?
The Central Nervous System Control of Respiration, Vol.209, pp.207-233
Progress in brain research, 209, Elsevier
2014
DOI: 10.1016/B978-0-444-63274-6.00011-4
PMCID: PMC4486262
PMID: 24746050
Abstract
Serotonin (5-hydroxytryptamine, 5-HT) neurons are widely considered to play an important role in central respiratory chemoreception. Although many studies in the past decades have supported this hypothesis, there had been concerns about its validity until recently. One recurring claim had been that 5-HT neurons are not consistently sensitive to hypercapnia in vivo. Another belief was that 5-HT neurons do not stimulate breathing; instead, they inhibit or modulate respiratory output. It was also believed by some that 5-HT neuron chemosensitivity is dependent on TASK channels, but mice with genetic deletion of TASK-1 and TASK-3 have a normal hypercapnic ventilatory response. This review explains why these principal arguments against the hypothesis are not supported by existing data. Despite repeated challenges, a large body of evidence now supports the conclusion that at least a subset of 5-HT neurons are central chemoreceptors.
Details
- Title: Subtitle
- Serotonin neurons and central respiratory chemoreception: where are we now?
- Creators
- Frida A Teran - St. Mary's University, One Camino Santa Maria, San Antonio, TX, USACory A Massey - Interdisciplinary Graduate Program in Neuroscience, University of Iowa Carver College of Medicine, Iowa City, IA, USA; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USAGeorge B Richerson - University of Iowa, Molecular Physiology and Biophysics
- Resource Type
- Book chapter
- Publication Details
- The Central Nervous System Control of Respiration, Vol.209, pp.207-233
- Series
- Progress in brain research; 209
- DOI
- 10.1016/B978-0-444-63274-6.00011-4
- PMID
- 24746050
- PMCID
- PMC4486262
- NLM abbreviation
- Prog Brain Res
- ISSN
- 0079-6123
- eISSN
- 1875-7855
- Publisher
- Elsevier; Netherlands
- Grant note
- R01 HL052539 / NHLBI NIH HHS R01 HD052772 / NICHD NIH HHS T32 GM007337 / NIGMS NIH HHS P01 HD036379 / NICHD NIH HHS U01 NS090414 / NINDS NIH HHS
- Language
- English
- Date published
- 2014
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984025081302771
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