SiRNA Delivery Vehicles

Aliasger K Salem; Mark A Behlke

doi:10.1002/9780470923733.ch6

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Book chapter

SiRNA Delivery Vehicles

Aliasger K Salem and Mark A Behlke

RNA Interference, pp.174-215

John Wiley & Sons, Inc

01/11/2011

DOI: 10.1002/9780470923733.ch6

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Abstract

This chapter contains sections titled: Introduction Nonviral Sirna Delivery Vehicles Pegylation of Delivery Vector Cell Targeting Ligand Conjugation to Sirna Delivery Vehicles Rationale Design of Modular Multicomponent Sirna Delivery Systems Conclusions References

SiRNA delivery vehicles, RNA interference (RNAi) ‐ method of choice, in suppressing gene expression In vitro

RNAi‐based therapeutics, by pharmaceutical and biotechnology companies ‐ RNAi, potent and versatile tool reducing targeted gene expression

use of delivery systems for synthetic small interfering RNAs (SiRNAS) ‐ overcoming limitations of SiRNAS, enhancing therapeutic efficacy

Details

Title: Subtitle: SiRNA Delivery Vehicles
Creators: Aliasger K Salem - Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
Mark A Behlke - Integrated DNA Technologies, Inc., 1710 Commercial Park, Coralville, IA 52241, USA
Contributors: Paul H Johnson (Editor)
Resource Type: Book chapter
Publication Details: RNA Interference, pp.174-215
DOI: 10.1002/9780470923733.ch6
Publisher: John Wiley & Sons, Inc; Hoboken, NJ, USA
Number of pages: 42
Language: English
Date published: 01/11/2011
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering
Record Identifier: 9983986688602771

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