Book chapter
Signal Transduction by Receptors for BAFF and APRIL
BLyS Ligands and Receptors, pp.93-114
Contemporary Immunology, Humana Press Inc
01/01/2010
DOI: 10.1007/978-1-60327-013-7_5
Abstract
The cytokines B-cell-activating factor of the TNF family (BAFF) and A proliferation-inducing ligand (APRIL) stimulate several of the major signaling cascades responsible for B-cell homeostasis. Transmitting these stimuli to the intracellular milieu are the receptors B-cell maturation antigen (BCMA), transmembrane activator and CAML interactor (TACI), and BAFF receptor (BAFFR). While evidence for the activation of several nuclear-independent pathways is accumulating, the most consistent, reproducibly detectable molecular effect of stimulating cells with BAFF or APRIL is activation of the NF-kappa B family of transcription factors. Here, we will summarize the current state of knowledge about BAFF and APRIL signaling; from the membrane-proximal events that are distinct to BCMA, TACI, and BAFFR to the differences in the downstream pathway types and kinetics that are manifest in the phenotypic extremes of their respective knockout mouse models.
Details
- Title: Subtitle
- Signal Transduction by Receptors for BAFF and APRIL
- Creators
- Joanne M. Hildebrand - Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USAPing Xie - Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USAGail A. Bishop - Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA
- Contributors
- M P Cancro (Editor)
- Resource Type
- Book chapter
- Publication Details
- BLyS Ligands and Receptors, pp.93-114
- Series
- Contemporary Immunology
- DOI
- 10.1007/978-1-60327-013-7_5
- Publisher
- Humana Press Inc; TOTOWA
- Number of pages
- 22
- Language
- English
- Date published
- 01/01/2010
- Academic Unit
- Microbiology and Immunology; President; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984297621002771
Metrics
3 Record Views