Book chapter
Single-Unit Extracellular Recording from the Cerebellum During Eyeblink Conditioning in Head-Fixed Mice
Extracellular Recording Approaches, pp.39-71
Neuromethods, Humana Press Inc
01/01/2018
DOI: 10.1007/978-1-4939-7549-5_3
PMCID: PMC6542276
PMID: 31156292
Abstract
This chapter presents a method for performing in vivo single-unit extracellular recordings and optogenetics during an associative, cerebellum-dependent learning task in head-fixed mice. The method uses a cylindrical treadmill system that reduces stress in the mice by allowing them to walk freely, yet it provides enough stability to maintain single-unit isolation of neurons for tens of minutes to hours. Using this system, we have investigated sensorimotor coding in the cerebellum while mice perform learned skilled movements.
Details
- Title: Subtitle
- Single-Unit Extracellular Recording from the Cerebellum During Eyeblink Conditioning in Head-Fixed Mice
- Creators
- Shane A. Heiney - Baylor College of MedicineShogo Ohmae - Baylor College of MedicineOlivia A. Kim - Baylor College of MedicineJavier F. Medina - Baylor College of Medicine
- Contributors
- R V Sillitoe (Editor)
- Resource Type
- Book chapter
- Publication Details
- Extracellular Recording Approaches, pp.39-71
- Series
- Neuromethods
- DOI
- 10.1007/978-1-4939-7549-5_3
- PMID
- 31156292
- PMCID
- PMC6542276
- NLM abbreviation
- Neuromethods
- eISSN
- 1940-6045
- ISSN
- 0893-2336
- Publisher
- Humana Press Inc; TOTOWA
- Number of pages
- 33
- Language
- English
- Date published
- 01/01/2018
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984622057102771
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