Book chapter
Sleeping Beauty Models of Cancer
Insertional Mutagenesis Strategies in Cancer Genetics, pp.113-130
Springer New York
10/21/2010
DOI: 10.1007/978-1-4419-7656-7_5
Abstract
The many advantages of retroviral insertional mutagenesis have been discussed in the previous chapters, and this strategy has played a significant role in furthering our current understanding of the genetic basis of cancer. However, retroviral insertional mutagenesis has two main limitations that have prevented this approach from being applied to many forms of cancer. First, naturally-occurring slow transforming retroviruses have a restricted cellular tropism within the infected host, thus limiting the types of cells that can be mutagenized by these viruses [29]. Second, retroviruses require the host cell to undergo mitosis in order to gain access to the nuclear genome and integrate as a provirus. The combined effects of these drawbacks have limited the application of retroviral insertional mutagenesis to the study of hematopoietic malignancies and mammary cancer in mice.
Details
- Title: Subtitle
- Sleeping Beauty Models of Cancer
- Creators
- Jesse D. Riordan - University of IowaLaura M. Rogers - University of IowaKatherine E. Berquam-Vrieze - University of IowaAdam J. Dupuy - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Book chapter
- Publication Details
- Insertional Mutagenesis Strategies in Cancer Genetics, pp.113-130
- DOI
- 10.1007/978-1-4419-7656-7_5
- Publisher
- Springer New York; New York, NY
- Language
- English
- Date published
- 10/21/2010
- Academic Unit
- Anatomy and Cell Biology; Pathology; Holden Comprehensive Cancer Center
- Record Identifier
- 9984284340902771
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