Book chapter
Strategies and Implications for Prime-Boost Vaccination to Generate Memory CD8 T Cells
Crossroads between Innate and Adaptive Immunity III, pp.69-83
Advances in Experimental Medicine and Biology, Springer New York
06/09/2011
DOI: 10.1007/978-1-4419-5632-3_7
PMID: 21842366
Abstract
Generating a large population of memory CD8 T cells is an appealing goal for vaccine design against a variety of human diseases. Indeed, experimental models have demonstrated that the overall number of memory CD8 T cells present at the time of infection correlates strongly with the ability to confer host protection against a range of different pathogens. Currently, the most conceivable approach to rapidly generate a large population of memory CD8 T cells is through the use of prime-boost vaccination. In addition, recent experimental findings have uncovered important principles that govern both the rate and magnitude of memory CD8 T cell formation. Thus, this has resulted in novel prime-boost vaccination strategies that could potentially be used in humans to generate protective populations of memory CD8 T cells.
Details
- Title: Subtitle
- Strategies and Implications for Prime-Boost Vaccination to Generate Memory CD8 T Cells
- Creators
- Jeffrey C NolzJohn T Harty - Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, USA
- Resource Type
- Book chapter
- Publication Details
- Crossroads between Innate and Adaptive Immunity III, pp.69-83
- Publisher
- Springer New York; New York, NY
- Series
- Advances in Experimental Medicine and Biology
- DOI
- 10.1007/978-1-4419-5632-3_7
- PMID
- 21842366
- ISSN
- 0065-2598
- Language
- English
- Date published
- 06/09/2011
- Academic Unit
- Pathology
- Record Identifier
- 9984046802002771
Metrics
15 Record Views