Book chapter
Synthesis of Oxygen‐15 Water ([15O]H2O)
Radiochemical Syntheses, pp.103-113
John Wiley & Sons, Inc
05/22/2015
DOI: 10.1002/9781118834114.ch11
Abstract
Oxygen‐15 is a cyclotron‐produced, positron‐emitting radionuclide with a half‐life of 124 s. Depending on target conditions, the oxygen‐15 produced in the cyclotron target may take on the form of [
15
O]O
2
, [
15
O]CO, or [15O]CO
2
. All radiochemical syntheses must be carried out using appropriate equipment in a facility authorized for the use of radioactive materials. There are numerous production routes for oxygen‐15, including
14
N(d,n)
15
O,
16
O(p,pn)
15
O [10], and
15
N(p,n)
15
O. The nitrogen‐15 production route is the only available production route for low‐energy proton‐only cyclotrons and is hampered by the expense of enriched nitrogen‐15 gas. The quality procedures of Oxygen‐15 Water ([
15
O]H
2
O) described in this chapter include: visual inspection, radionuclidic identity, radionuclidic purity, radiochemical and chemical purity, and sterility testing.
Details
- Title: Subtitle
- Synthesis of Oxygen‐15 Water ([15O]H2O)
- Creators
- David W Dick - University of IowaG Leonard Watkins - Department of Radiology, University of Iowa Hospitals & Clinics, Iowa City, Iowa, USA
- Contributors
- Peter J. H Scott (Editor)
- Resource Type
- Book chapter
- Publication Details
- Radiochemical Syntheses, pp.103-113
- DOI
- 10.1002/9781118834114.ch11
- Publisher
- John Wiley & Sons, Inc; Hoboken, NJ
- Number of pages
- 10
- Language
- English
- Date published
- 05/22/2015
- Academic Unit
- Radiology; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984318706902771
Metrics
36 Record Views