Book chapter
T1 black holes and gray matter damage
Neurodegeneration in Multiple Sclerosis, pp.37-45
Topics in Neuroscience, Springer Nature
2007
DOI: 10.1007/978-88-470-0391-0_4
Abstract
Magnetic resonance imaging (MRI) has become important in the early diagnosis and monitoring of various neurologic disorders including multiple sclerosis (MS). MRI has emerged as a key supportive therapeutic outcome measure in MS-related clinical trials. The limitations of conventional MRI surrogates have driven researchers to develop better biomarkers, including those capturing destructive aspects of the disease. In this chapter, we discuss the most recent data highlighting the role of hypointense lesions on T1-weighted images (black holes; BH) and gray matter (GM) damage in the MRI assessment of MS. We focus on the most relevant pathologic, MRI, and clinical correlation studies addressing BH and GM injury.
Details
- Title: Subtitle
- T1 black holes and gray matter damage
- Creators
- M. Neema - Brigham and Women's HospitalV. S. R. Dandamudi - Brigham and Women's HospitalA. Arora - Brigham and Women's HospitalJ. Stankiewicz - Brigham and Women's HospitalR. Bakshi - Brigham and Women's Hospital
- Contributors
- M Filippi (Editor)M Rovaris (Editor)G Comi (Editor)
- Resource Type
- Book chapter
- Publication Details
- Neurodegeneration in Multiple Sclerosis, pp.37-45
- Publisher
- Springer Nature; Milan
- Series
- Topics in Neuroscience
- DOI
- 10.1007/978-88-470-0391-0_4
- Number of pages
- 3
- Grant note
- RG 3574A1 and RG 3705A1 / National Multiple Sclerosis Society NIH-NINDS 1 K23 NS42379-01 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 2007
- Academic Unit
- Psychiatry
- Record Identifier
- 9984632141402771
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