Book chapter
TEL/ETV6 Gene Rearrangements in Human Leukemias
Transcription Factors, pp.425-445
John Wiley & Sons, Inc
12/15/2000
DOI: 10.1002/0471223883.ch24
Abstract
Although many questions remain about the molecular mechanisms of transformation, clinically useful insights have been gained from analysis of hematologic malignancies that harbor TEL gene rearrangements. Analysis of the TEL‐tyrosine kinase fusions has demonstrated that at a minimum the kinase is an appropriate and tenable target for therapeutic intervention, and that some downstream effectors of transformation such as Stat family members may also be potential targets for drug development.
Details
- Title: Subtitle
- TEL/ETV6 Gene Rearrangements in Human Leukemias
- Creators
- Ema Anastasiadou - CircleMichael H Tomasson - CircleDavid W Sternberg - CircleTodd R Golub - CircleD. Gary Gilliland - Circle
- Contributors
- Katya Ravid (Editor) - Boston University School of MedicineJonathan D Licht (Editor) - Icahn School of Medicine at Mount Sinai
- Resource Type
- Book chapter
- Publication Details
- Transcription Factors, pp.425-445
- Publisher
- John Wiley & Sons, Inc; New York, USA
- DOI
- 10.1002/0471223883.ch24
- Number of pages
- 21
- Language
- English
- Date published
- 12/15/2000
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984363285502771
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