Targeting Tumor Metabolism to Overcome Radioresistance

Daniel Wahl; Michael Petronek; Rashmi Ramachandran; John Floberg; Bryan G. Allen; Julie K. Schwarz

doi:10.1007/978-3-030-49701-9_10

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Targeting Tumor Metabolism to Overcome Radioresistance

Book chapter

Peer reviewed

Targeting Tumor Metabolism to Overcome Radioresistance

Daniel Wahl, Michael Petronek, Rashmi Ramachandran, John Floberg, Bryan G. Allen and Julie K. Schwarz

Molecular Targeted Radiosensitizers, pp.219-263

Cancer Drug Discovery and Development, Springer International Publishing

08/11/2020

DOI: 10.1007/978-3-030-49701-9_10

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Abstract

Metabolic reprogramming is a hallmark of cancer. Altered metabolism provides a survival advantage for cancer cells during tumorigenesis by supplying resources needed for uncontrolled growth and increased rates of cell division. As tumors grow beyond the limits of diffusion, altered metabolism provides a selective advantage in the context of nutrient deprivation. Many cancer therapies, including radiation, are known to impact tumor metabolism while the metabolic state of a cancer may contribute to radioresistance. Preclinical and clinical evidence exists to support combinations of radiation therapy with drugs that affect, for example, oxidative, glucose, glutamine, one-carbon, nucleotide, or iron metabolism in cancers. Work is ongoing to determine optimal strategies for combining these drugs with conventionally fractionated and hypofractionated radiation schemes. New strategies, including dietary manipulation during the course of radiation therapy, are currently being explored. Targeting tumor metabolism is a rapidly evolving and promising field of oncology and will be reviewed here in more detail.

Ascorbate

Calorie restriction

Glucose metabolism

Glutaminolysis

Glycolysis

Hallmarks of cancer

Iron metabolism

Ketogenic diet

Metabolic reprogramming

NAD

NADP

Nucleoside analogs

Nucleotide metabolism

One-carbon metabolism

Pentose phosphate pathway

Radioresistance

Ribonucleotide reductase

Thymidylate synthase

Details

Title: Subtitle: Targeting Tumor Metabolism to Overcome Radioresistance
Creators: Daniel Wahl - University of Michigan–Ann Arbor
Michael Petronek - University of Iowa
Rashmi Ramachandran - Washington University in St. Louis
John Floberg - Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Milwaukee, USA
Bryan G. Allen - Roy J. and Lucille A. Carver College of Medicine
Julie K. Schwarz
Resource Type: Book chapter
Publication Details: Molecular Targeted Radiosensitizers, pp.219-263
Publisher: Springer International Publishing; Cham
Series: Cancer Drug Discovery and Development
DOI: 10.1007/978-3-030-49701-9_10
eISSN: 2196-9914
ISSN: 2196-9906
Language: English
Date published: 08/11/2020
Academic Unit: Radiation Oncology; Iowa Neuroscience Institute
Record Identifier: 9984313080702771

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