Book chapter
The DOCA-Salt Model of Hypertension for Studies of Cerebrovascular Function, Stroke, and Brain Health
Neural Repair, pp.481-487
Methods in Molecular Biology, 2616, Springer US
01/31/2023
DOI: 10.1007/978-1-0716-2926-0_34
PMID: 36715955
Abstract
The brain renin-angiotensin-aldosterone system (RAAS) regulates many physiological processes including fluid and electrolyte balance, vascular structure and function, blood pressure, cognition, and other aspects of brain function. Treatment with the mineralocorticoid deoxycorticosterone acetate and salt stimulates the local RAAS within the brain. In this chapter, we describe the surgical procedures used to induce activation of the brain RAAS with deoxycorticosterone acetate and salt. This technique can be used for studies of hypertension, cerebrovascular biology and dysfunction, and other diseases that impact brain health.
Details
- Title: Subtitle
- The DOCA-Salt Model of Hypertension for Studies of Cerebrovascular Function, Stroke, and Brain Health
- Creators
- T. Michael De Silva - La Trobe UniversityFrank M. Faraci - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Book chapter
- Publication Details
- Neural Repair, pp.481-487
- Publisher
- Springer US; New York, NY
- Series
- Methods in Molecular Biology; 2616
- DOI
- 10.1007/978-1-0716-2926-0_34
- PMID
- 36715955
- eISSN
- 1940-6029
- ISSN
- 1064-3745
- Language
- English
- Date published
- 01/31/2023
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984364513402771
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