Book chapter
The Gut Microbiome and Metabolome in Multiple Sclerosis
Microbiome and metabolome in diagnosis, therapy, and other strategic applications, pp.333-340
Elsevier
2019
DOI: 10.1016/B978-0-12-815249-2.00034-8
Abstract
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), characterized by demyelination, axonal damage, and progressive neurologic disability. The fact that there is only 30% concordance in MS risk, between monozygotic twins, suggests that environmental factor(s) plays a major role in disease development. The gut microbiota has emerged as a potential environmental factor, linked with a susceptibility to provide protection from MS. However, it is unclear how the gut microbiota inhibits aberrant activation of the immune system, to prevent CNS targeting and destruction. A better understanding of the influence of the gut microbiota and the associated metabolic pathways on the immune system may lead to the identification of potential therapeutic agents.
Details
- Title: Subtitle
- The Gut Microbiome and Metabolome in Multiple Sclerosis
- Creators
- Shailendra Giri - University of Iowa, PathologyAshutosh K Mangalam - University of Iowa, Pathology
- Resource Type
- Book chapter
- Publication Details
- Microbiome and metabolome in diagnosis, therapy, and other strategic applications, pp.333-340
- DOI
- 10.1016/B978-0-12-815249-2.00034-8
- Publisher
- Elsevier; London
- Number of pages
- xxxi, 472 pages
- Alternative title
- Microbiome and metabolome in diagnosis, therapy, and other strategic applications (Online)
- Language
- English
- Date published
- 2019
- Academic Unit
- Pathology; Iowa Neuroscience Institute
- Record Identifier
- 9984223159302771
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