Book chapter
The Human Genome Project and Personalized Medicine
Pathobiology of Human Disease, pp.3418-3422
Elsevier Inc
2014
DOI: 10.1016/B978-0-12-386456-7.06604-1
Abstract
The goal of personalized medicine is to use detailed information extracted from a patient's tissue sample to guide the use of individualized therapies to target the specific molecular etiology of a patient's disease. In this article, we discuss the role of the Human Genome Project in enabling studies into the genetic etiology of disease. We discuss notable examples (acute promyelocytic leukemia and non-small-cell lung cancer) where this genetic knowledge has led to improved personalized treatments for patients, in which a targeted therapy is given to treat a genetically defined disease subtype. Lastly, we discuss major challenges to the field of personalized medicine – including the emergence of resistance to targeted therapies – as well as new opportunities afforded by the rapid decrease in the costs of genome sequencing.
Details
- Title: Subtitle
- The Human Genome Project and Personalized Medicine
- Creators
- M.M HeftiA.H Beck
- Resource Type
- Book chapter
- Publication Details
- Pathobiology of Human Disease, pp.3418-3422
- DOI
- 10.1016/B978-0-12-386456-7.06604-1
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 2014
- Academic Unit
- Pathology; Iowa Neuroscience Institute
- Record Identifier
- 9984070130802771
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