Book chapter
The Natural History of Cerebral Aneurysms
Neurobiology of Disease, pp.785-794
Oxford University Press
08/01/2016
DOI: 10.1093/med/9780199937837.003.0109
Abstract
Subarachnoid hemorrhage (SAH) secondary to rupture of cerebral aneurysms represents a relatively small fraction of strokes (5%) but morbidity and mortality associated with aneurysm rupture remain very high despite advances in the treatment of aneurysmal SAH. Cerebral vasospasm (CV) is the leading cause of delayed morbidity and mortality following aneurysmal subarachnoid hemorrhage, as well as delayed neurological dysfunction 1 to 2 weeks after rupture. Endothelial dysfunction is one of the primary contributing factors to CV following aneurysmal SAH, and this is associated with alterations in intracellular adhesion molecule1 (ICAM1), matrix metalloproteinases (MM), and the bloodbrain barrier[p63].
Details
- Title: Subtitle
- The Natural History of Cerebral Aneurysms
- Creators
- David Hasan
- Resource Type
- Book chapter
- Publication Details
- Neurobiology of Disease, pp.785-794
- Publisher
- Oxford University Press
- DOI
- 10.1093/med/9780199937837.003.0109
- Alternative title
- Section VII Cerebrovascular Diseases
- Language
- English
- Date published
- 08/01/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering
- Record Identifier
- 9984419016302771
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