Book chapter
The Pathophysiology of Celiac Disease
Celiac Disease, pp.39-51
Clinical Gastroenterology, Springer New York
10/17/2013
DOI: 10.1007/978-1-4614-8560-5_4
Abstract
Over the last 25 years, with the concerted effort of many researchers, we have learned a lot about the pathophysiology of celiac disease (CD). Now, CD is the best understood autoimmune/immune-mediated illness. This chapter will discuss current understanding of gluten as an antigen, antigen-presentation, and the role of HLA-DQ2/DQ8, how gluten peptides cross the intestinal epithelial cell barrier, the importance of tissue transglutaminase for modifying gluten peptides for presentation, the role of intestinal T cells in coordinating inflammation, how intraepithelial lymphocytes are triggered to attack intestinal epithelial cells, and the role of antibody response.
Details
- Title: Subtitle
- The Pathophysiology of Celiac Disease
- Creators
- David E. Elliott - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Book chapter
- Publication Details
- Celiac Disease, pp.39-51
- Publisher
- Springer New York; New York, NY
- Series
- Clinical Gastroenterology
- DOI
- 10.1007/978-1-4614-8560-5_4
- eISSN
- 2197-7704
- ISSN
- 2197-7399
- Language
- English
- Date published
- 10/17/2013
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984362735902771
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