Book chapter
The Role of Akt Pathway Signaling in Glucose Metabolism and Metabolic Oxidative Stress
Oxidative Stress in Cancer Biology and Therapy, pp.21-46
Oxidative Stress in Applied Basic Research and Clinical Practice, Humana Press
10/21/2011
DOI: 10.1007/978-1-61779-397-4_2
Abstract
Glucose metabolism plays an important role in hydroperoxide detoxification and the inhibition of glucose metabolism has been shown to increase prooxidant production and cytotoxicity in cancer cells. Increased Akt pathway signaling has been shown to be directly correlated with increased rates of glucose metabolism observed in cancer cells versus normal cells. These observations have led to the proposal that inhibition of Akt signaling would inhibit glycolysis and increase hydroperoxide production which would preferentially kill tumor cells versus normal cells via oxidative stress. The current study shows that inhibition of the Akt pathway inhibits glucose consumption and induces parameters indicative of oxidative stress such as glutathione disulfide (%GSSG) and thioredoxin reductase (TR) activity in human head and neck cancer (HNSCC) cells. A theoretical model to explain the results is presented and implications for the use of Akt pathway inhibitors in combination with glycolytic inhibitors and/or manipulations that increase prooxidant production are discussed.
Details
- Title: Subtitle
- The Role of Akt Pathway Signaling in Glucose Metabolism and Metabolic Oxidative Stress
- Creators
- Andrean L Simons - University of IowaKevin P Orcutt - University of IowaJoshua M Madsen - University of IowaPeter M Scarbrough - University of IowaDouglas R Spitz - University of Iowa
- Resource Type
- Book chapter
- Publication Details
- Oxidative Stress in Cancer Biology and Therapy, pp.21-46
- Series
- Oxidative Stress in Applied Basic Research and Clinical Practice
- DOI
- 10.1007/978-1-61779-397-4_2
- Publisher
- Humana Press; Totowa, NJ
- Language
- English
- Date published
- 10/21/2011
- Academic Unit
- Oral Pathology, Radiology and Medicine; Pathology; Pharmaceutical Sciences and Experimental Therapeutics; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984186550202771
Metrics
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