Book chapter
The Role of Inflammation in the Generation and Maintenance of Memory T Cells
Memory T Cells, pp.42-56
Advances in Experimental Medicine and Biology, Springer New York
2010
DOI: 10.1007/978-1-4419-6451-9_4
PMID: 20795539
Abstract
Following infection or vaccination, antigen-specific T cells undergo enormous expansion in numbers and differentiate into effector cells that control infection and modulate other aspects of innate and adaptive immunity. The effector T-cell expansion phase is followed by an abrupt period of contraction, during which 90–95% of antigen-specific T cells are eliminated. The surviving pool of T cells subsequently differentiates into long-lived memory populations that can persist for the life of the host and mediate enhanced protective immunity following pathogen re-infection. The generation and maintenance of memory T-cell populations are influenced by a multitude of factors, including inflammatory cytokines that can act on T cells at various points during their differentiation. Herein, we discuss our current understanding of how inflammation shapes not only the quantity and quality of memory T cells, but also the rate at which functional memory T-cell populations develop.
Details
- Title: Subtitle
- The Role of Inflammation in the Generation and Maintenance of Memory T Cells
- Creators
- Noah S Butler - Department of Microbiology, University of Iowa, Iowa City, USAJohn T Harty - Department of Microbiology, University of Iowa, Iowa City, USA
- Resource Type
- Book chapter
- Publication Details
- Memory T Cells, pp.42-56
- Publisher
- Springer New York; New York, NY
- Series
- Advances in Experimental Medicine and Biology
- DOI
- 10.1007/978-1-4419-6451-9_4
- PMID
- 20795539
- ISSN
- 0065-2598
- Language
- English
- Date published
- 2010
- Academic Unit
- Microbiology and Immunology; Pathology
- Record Identifier
- 9984002384702771
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