Book chapter
The adaptive immune response to respiratory syncytial virus
Challenges and Opportunities for Respiratory Syncytial Virus Vaccines, pp.155-171
Current topics in microbiology and immunology, 372, Springer-Verlag
2013
DOI: 10.1007/978-3-642-38919-1_8
PMID: 24362689
Abstract
Respiratory syncytial virus (RSV) causes severe respiratory disease in children, the elderly and immunocompromised individuals. The combined actions of CD4 and CD8 T cells play a critical role in terminating an acute RSV infection whereas antibodies can provide protection from re-infection. Despite eliciting an immune response that mediates clearance of the virus, immunity to the virus appears to wane over time and individuals remain susceptible to reinfection with RSV throughout their lifetime. The ineffectiveness of the natural infection to induce long-term immunity has hampered vaccine efforts and there is currently no licensed RSV vaccine. In this review, we summarize our current understanding of the adaptive immune response to RSV and its contribution to disease.
Details
- Title: Subtitle
- The adaptive immune response to respiratory syncytial virus
- Creators
- Steven M Varga - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, 52242, USA, steven-varga@uiowa.eduThomas J Braciale
- Resource Type
- Book chapter
- Publication Details
- Challenges and Opportunities for Respiratory Syncytial Virus Vaccines, pp.155-171
- Publisher
- Springer-Verlag
- Series
- Current topics in microbiology and immunology; 372
- DOI
- 10.1007/978-3-642-38919-1_8
- PMID
- 24362689
- eISBN
- 3642389198; 9783642389191
- ISSN
- 0070-217X
- eISSN
- 2196-9965
- Grant note
- R01 AI037293 / NIAID NIH HHS R01 HL033391 / NHLBI NIH HHS
- Language
- English
- Date published
- 2013
- Academic Unit
- Graduate College Admin and Gen; Microbiology and Immunology; Pathology
- Record Identifier
- 9984083899802771
Metrics
20 Record Views