Book chapter
The cAMP/PKA Pathway and the Modeling of Human Memory Disorders in Mice
Advances in Psychology, pp.301-315
Elsevier Science & Technology
2008
DOI: 10.1016/S0166-4115(08)10024-3
Abstract
This chapter focuses on three classes of memory disorders: Alzheimer's disease (AD), mental retardation (MR), and schizophrenia. There is strong evidence that perturbations in the cAMP/PKA signaling system may be related to the memory problems in each disorder. The chapter reviews each disorder and discusses the evidence that disruptions in the cAMP/PKA pathway are at least partially responsible for the memory impairments. Although there are a number of putative mouse models of AD, the most common are transgenic mice over- or under-expressing the genes thought to be important in AD pathology. There are a number of reports that implicate the cAMP/PKA pathway in the symptom complex of AD. Early in the course of the disease is where the cAMP/PKA system may be impacted and also may represent a novel therapeutic target. There are several types of MR that are characterized by alterations in the cAMP/PKA pathway. A number of converging lines of evidence point to dysregulation in the cAMP/PKA pathway in schizophrenia. The chapter discusses novel treatment options that build on increasing knowledge of intracellular signaling pathways.
Details
- Title: Subtitle
- The cAMP/PKA Pathway and the Modeling of Human Memory Disorders in Mice
- Creators
- Francis X Brennan - RedPoint Bio CorporationTed Abel - Department of Biology, University of Pennsylvania
- Resource Type
- Book chapter
- Publication Details
- Advances in Psychology, pp.301-315
- Publisher
- Elsevier Science & Technology
- DOI
- 10.1016/S0166-4115(08)10024-3
- ISSN
- 0166-4115
- Language
- English
- Date published
- 2008
- Academic Unit
- Psychological and Brain Sciences; Biochemistry and Molecular Biology; Neuroscience and Pharmacology; Molecular Physiology and Biophysics; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984065832302771
Metrics
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