Book chapter
The human glucagon-like peptide-1 (GLP-1) receptor. Cloning and functional expression
Physiology and Pathophysiology of the Islets of Langerhans, Vol.426, pp.113-119
Advances in experimental medicine and biology, 426, Springer
1997
DOI: 10.1007/978-1-4899-1819-2_15
PMID: 9544263
Abstract
At similar plasma glucose concentrations much greater insulin secretion is achieved with oral glucose than with intravenous glucose. These observations lead to the concept that gastrointestinal factors (incretins) are released by nutrients, particularly glucose, to potentiate insulin release (Creutzfeldt, 1979). The two most potent incretins, GLP-1(7–37) and its amidated form GLP-1(7–36 amide), are processed from the parent 37 amino acid GLP-1 peptide, which is produced in intestinal L-cells as a posttranslational product of preproglucagon.
Details
- Title: Subtitle
- The human glucagon-like peptide-1 (GLP-1) receptor. Cloning and functional expression
- Creators
- Joseph S Dillon - Division of Endocrinology, Diabetes, Metabolism and Molecular Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USAMichael B WheelerXing-Hong LengB Brooke LigonAubrey E Boyd III
- Resource Type
- Book chapter
- Publication Details
- Physiology and Pathophysiology of the Islets of Langerhans, Vol.426, pp.113-119
- Publisher
- Springer; Boston, MA
- Series
- Advances in experimental medicine and biology; 426
- DOI
- 10.1007/978-1-4899-1819-2_15
- PMID
- 9544263
- ISSN
- 0065-2598
- Grant note
- RR00054 / NCRR NIH HHS DK34447 / NIDDK NIH HHS
- Language
- English
- Date published
- 1997
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094615802771
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